Before scanning using SystemNinja v2.3.4 I backup the system registry using windows7Manager v4.0.7 also check the installed apps integrity via Windows Uninstall & Your Unistaller! Pro v7.4.2012.05 to see if all are ok then I clean the junk files then recheck the installed apps via the above utility and discovered the dotNET4 are corrupted then I tried to repair the dotNET4 to its original status via dotNET4 reinstall process, the problem persist.
However, a complete uninstall & reinstall of dotNET4 cure the problem.
Thnks & Regards.